News June 30th, 2023

Developing a rapid molecular diagnostic platform

We’re excited to be partnering with Linear Diagnostics to develop a rapid molecular diagnostic platform.

University of Birmingham spinout, Linear Diagnostics Limited, has received funding to finesse a point-of-care test for rapid diagnosis of gonorrhoea and chlamydia in men who have sex with men (MSM), and women who have sex with women (WSW).

The funding from the NIHR (National Institute for Health and Care Research) will cover essential work to optimise and validate Linear’s platform technology (LDx-CTNG), so it can diagnose infection from rectal and pharyngeal (throat) swabs.

Linear Diagnostics’ technology was invented by Professor, Tim Dafforn, and uses linear dichroism, where a beam of polarised light detects multiple targets from a single sample. A proof of concept study has already shown this technology can provide a fast, accurate diagnostic test, helping to limit the spread of disease. The platform will also benefit from a new rapid isothermal DNA amplification technique that is simpler than many existing technologies.

Gonorrhoea and chlamydia are both major public health concerns. While chlamydia remains the most commonly detected sexually transmitted infection, the UK Health Security Agency recently warned of a surge in gonorrhoea cases. The latest figures show the number of cases increased 50% from 2021 to 2022, and while gonorrhoea is increasing in people of all ages, the rise is highest among young people aged 15 to 24 years. This increase in cases and also the rapid increase in multi-drug resistant gonorrhoea, highlights the risk to public health.

The most commonly used tests require laboratory processing, meaning it can be days or even weeks between taking a sample and getting a result. Linear’s technology will enable a result within minutes, reducing patient anxiety, the spread of disease and improving outcomes. Our experienced in vitro diagnostics team is looking forward to working with Linear to develop a new product platform around this technology.

A person wearing a white lab coat working on a diagnostics device
Brendan Farrell, Chairman of Linear Diagnostics

For STIs, the rapidity of the testing procedure is key, as patients prefer to get test results quickly and start treatment immediately. We are aiming to produce a testing platform that will meet the WHO stipulations of being easy to use with minimal training, so people can present for testing and collect their treatment in a single visit.

- Brendan Farrell, Chairman of Linear Diagnostics

Linear Diagnostics are now seeking development partners. Companies interested in partnering with Linear Diagnostics should email info@lineardiagnostics.com

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